In the game-searchable era (since 1916), there is something that has happened during a major league game only 4 times, specifically in the games below.
What is it?
1923-06-06 – White Sox 4, Yankees 1, Red Faber homered off of Herb Pennock
1929-06-24 – Tigers 13, White Sox 4, Red Faber homered off of Emil Yde
1948-09-20 – Phillies 5, Pirates 2, Bob Chesnes homered off of Robin Roberts
1962-05-05 – Athletics 18, Indians 6, Jerry Walker homered off of Pedro Ramos
Happy sleuthing!
Congratulations to Stuart! He correctly identified the above games as the only contests since 1916 to feature a home run hit by a switch-hitting pitcher off of another switch-hitting pitcher who also homered in his career. Thanks to Baseball-Reference.com for the home runs logs.